Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort (2024)

Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort (1)

  • Subscribe
  • Log In More

    Log in via Institution

    Log in via OpenAthens

    Log in via BSG

    Log in using your username and password

  • Basket
  • Search More

    Advanced search

  • CME/CPD
  • Latest content
  • Current issue
  • Archive
  • Authors
  • About

You are here

  • Home
  • Online First
  • Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort

Email alerts

Article Text

Article menu

  • Article Text
  • Article info
  • Citation Tools
  • Share
  • Rapid Responses
  • Article metrics
  • Alerts

PDF

Original research

Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort

  1. http://orcid.org/0000-0002-3565-9302Gregory A Coté1,
  2. http://orcid.org/0000-0002-9389-1927Badih Joseph Elmunzer2,
  3. Haley Nitchie3,
  4. Richard S Kwon4,
  5. Field Willingham5,
  6. http://orcid.org/0000-0002-2935-0560Sachin Wani6,
  7. Vladimir Kushnir7,
  8. http://orcid.org/0000-0002-0021-7862Amitabh Chak8,
  9. http://orcid.org/0000-0002-7577-3521Vikesh Singh9,
  10. Georgios I Papachristou10,
  11. Adam Slivka11,
  12. Martin Freeman12,
  13. Srinivas Gaddam13,
  14. Priya Jamidar14,
  15. Paul Tarnasky15,
  16. Shyam Varadarajulu16,
  17. Lydia D Foster17,
  18. Peter Cotton18
  1. 1Department of Medicine, Division of Gastroenterology & Hepatology, Oregon Health & Science University, Portland, Oregon, USA
  2. 2Gastroenterology, Medical University of South Carolina, Charleston, South Carolina, USA
  3. 3Department of Medicine, Division of Gastroenterology & Hepatology, Medical University of South Carolina, Charleston, South Carolina, USA
  4. 4Medicine/Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA
  5. 5Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia, USA
  6. 6School of Medicine, University of Colorado—Anschutz Medical Campus, Aurora, Colorado, USA
  7. 7Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
  8. 8Division of Gastroenterology and Liver Disease, University Hospitals Case Medical Center, Cleveland, Ohio, USA
  9. 9Gastroenterology, Johns Hopkins Hospital, Baltimore, Maryland, USA
  10. 10Department of Medicine, Division of Gastroenterology & Hepatology, The Ohio State University, Columbus, Ohio, USA
  11. 11Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
  12. 12University of Minnessota, Minneapolis, Minnesota, USA
  13. 13Cedars-Sinai Medical Center, Los Angeles, California, USA
  14. 14Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
  15. 15Methodist Digestive Institute, Dallas, Texas, USA
  16. 16Digestive Health Institute, Orlando, Florida, USA
  17. 17Department of Public Health Science, Medical University of South Carolina, Charleston, South Carolina, USA
  18. 18Medicine, DDC, Medical University of South Carolina, Charleston, South Carolina, USA
  1. Correspondence to Dr Gregory A Coté, Department of Medicine, Division of Gastroenterology & Hepatology, Oregon Health & Science University, Portland, OR 97239, USA; coteg{at}ohsu.edu

Abstract

Objective Sphincter of Oddi disorders (SOD) are contentious conditions in patients whose abdominal pain, idiopathic acute pancreatitis (iAP) might arise from pressurisation at the sphincter of Oddi. The present study aimed to measure the benefit of sphincterotomy for suspected SOD.

Design Prospective cohort conducted at 14 US centres with 12 months follow-up. Patients undergoing first-time endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy for suspected SOD were eligible: pancreatobiliary-type pain with or without iAP. The primary outcome was defined as the composite of improvement by Patient Global Impression of Change (PGIC), no new or increased opioids and no repeat intervention. Missing data were addressed by hierarchal, multiple imputation scheme.

Results Of 316 screened, 213 were enrolled with 190 (89.2%) of these having a dilated bile duct, abnormal labs, iAP or some combination. By imputation, an average of 122/213 (57.4% (95% CI 50.4% to 64.4%)) improved; response rate was similar for those with complete follow-up (99/161, 61.5% (54.0% to 69.0%)); of these, 118 (73.3%) improved by PGIC alone. Duct size, elevated labs and patient characteristics were not associated with response. AP occurred in 37/213 (17.4%) at a median of 6 months post ERCP and was more likely in those with a history of AP (30.9% vs 2.9%, p<0.0001).

Conclusion Nearly 60% of patients undergoing ERCP for suspected SOD improve, although the contribution of a placebo response is unknown. Contrary to prevailing belief, duct size and labs are poor response predictors. AP recurrence was common and like observations from prior non-intervention cohorts, suggesting no benefit of sphincterotomy in mitigating future AP episodes.

  • ABDOMINAL PAIN
  • FUNCTIONAL BOWEL DISORDER
  • ACUTE PANCREATITIS
  • ENDOSCOPIC RETROGRADE PANCREATOGRAPHY
  • ENDOSCOPIC SPHINCTEROTOMY

Data availability statement

Data are available upon reasonable request.

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    • ABDOMINAL PAIN
    • FUNCTIONAL BOWEL DISORDER
    • ACUTE PANCREATITIS
    • ENDOSCOPIC RETROGRADE PANCREATOGRAPHY
    • ENDOSCOPIC SPHINCTEROTOMY

    Data availability statement

    Data are available upon reasonable request.

    View Full Text

    Footnotes

    • Contributors GAC is the guarantor of this article. Each author contributed substantially to this paper through: (1) substantial contributions to the conception or design of the work; or the acquisition, analysis or interpretation of data for the work; (2) drafting the work or revising it critically for important intellectual content; (3) final approval of the version to be published; and (4) agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

    • Funding Research reported in this publication was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health under award number R01DK115495 (Cote, Foster, Cotton).

    • Disclaimer The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.

    Read the full text or download the PDF:

    Subscribe

    Log in via Institution

    Log in via OpenAthens

    Log in via BSG

    Log in using your username and password

    Read the full text or download the PDF:

    Subscribe

    Log in via Institution

    Log in via OpenAthens

    Log in via BSG

    Log in using your username and password

    Sphincterotomy for biliary sphincter of Oddi disorder and idiopathic acute recurrent pancreatitis: the RESPOnD longitudinal cohort (2024)
    Top Articles
    Margin Accounts vs. Cash Accounts - A Complete Guide
    What is Bankruptcy? Definition of Bankruptcy, Bankruptcy Meaning - The Economic Times
    Funny Roblox Id Codes 2023
    Golden Abyss - Chapter 5 - Lunar_Angel
    Www.paystubportal.com/7-11 Login
    Joi Databas
    DPhil Research - List of thesis titles
    Shs Games 1V1 Lol
    Evil Dead Rise Showtimes Near Massena Movieplex
    Steamy Afternoon With Handsome Fernando
    Which aspects are important in sales |#1 Prospection
    Detroit Lions 50 50
    18443168434
    Zürich Stadion Letzigrund detailed interactive seating plan with seat & row numbers | Sitzplan Saalplan with Sitzplatz & Reihen Nummerierung
    Grace Caroline Deepfake
    978-0137606801
    Nwi Arrests Lake County
    Justified Official Series Trailer
    London Ups Store
    Committees Of Correspondence | Encyclopedia.com
    Pizza Hut In Dinuba
    Jinx Chapter 24: Release Date, Spoilers & Where To Read - OtakuKart
    Obsidian Guard's Cutlass
    Marvon McCray Update: Did He Pass Away Or Is He Still Alive?
    Mccain Agportal
    Amih Stocktwits
    Fort Mccoy Fire Map
    Uta Kinesiology Advising
    Kcwi Tv Schedule
    What Time Does Walmart Auto Center Open
    Nesb Routing Number
    Olivia Maeday
    Random Bibleizer
    10 Best Places to Go and Things to Know for a Trip to the Hickory M...
    Black Lion Backpack And Glider Voucher
    Gopher Carts Pensacola Beach
    Duke University Transcript Request
    Lincoln Financial Field, section 110, row 4, home of Philadelphia Eagles, Temple Owls, page 1
    Jambus - Definition, Beispiele, Merkmale, Wirkung
    Netherforged Lavaproof Boots
    Ark Unlock All Skins Command
    Craigslist Red Wing Mn
    D3 Boards
    Jail View Sumter
    Nancy Pazelt Obituary
    Birmingham City Schools Clever Login
    Thotsbook Com
    Funkin' on the Heights
    Vci Classified Paducah
    Www Pig11 Net
    Ty Glass Sentenced
    Latest Posts
    Article information

    Author: Rev. Porsche Oberbrunner

    Last Updated:

    Views: 6255

    Rating: 4.2 / 5 (73 voted)

    Reviews: 80% of readers found this page helpful

    Author information

    Name: Rev. Porsche Oberbrunner

    Birthday: 1994-06-25

    Address: Suite 153 582 Lubowitz Walks, Port Alfredoborough, IN 72879-2838

    Phone: +128413562823324

    Job: IT Strategist

    Hobby: Video gaming, Basketball, Web surfing, Book restoration, Jogging, Shooting, Fishing

    Introduction: My name is Rev. Porsche Oberbrunner, I am a zany, graceful, talented, witty, determined, shiny, enchanting person who loves writing and wants to share my knowledge and understanding with you.